ANGIOGENESIS

Think of the circulatory system as the highway of the red blood cells. Red blood cells carry oxygen to the target tissues for nutrition and take away the carbon dioxide for garbage. It can be a rough ride down the pathways if there are potholes on the road or if there is heavy traffic along the route. Turbulence harms the fragile red blood cells, much like it would likely cause damage to your vehicle.  Blood vessels compose our circulatory system and are burdened by damage caused by cholesterol plaques, smoking, excessive sugar consumption, etc. These insults cause inflammation and fibrosis leading to the breakdown of a smooth ride for the oxygenated red blood cells.

Our bodies are built with internal mechanisms to help heal the damage caused by daily life, bad choices and genetic consequences. Growth factors are naturally secreted from blood components called platelets that are important to repair, wound healing, and growth. Although many growth factors exhibit angiogenic activity, most evidence points to a special role for Vascular endothelial growth factors (VEGF), also called vascular permeability factor, that promote blood vessel formation in early development (vaculogenesis) and have a central role in the growth of new blood vessels (angiogenesis)¹.

Low-intensity extracorporal shock wave (LI-ESWT) causes a sort of “microtrauma” to the tissues which then release angiogenic factors such as nitric oxide synthase and VEGF and also causes the release of endothelial cell proliferation factors such as proliferating cell nuclear antigen. Studies show that LI-ESWT, like RegenerWave™, elevates the angiogenic marker levels within a few days post-therapy and the levels remain high for almost 2 months²! This is important to understand in the treatment of vasculogenic erectile dysfunction. Kalyvianakis, a leading researcher in the use of LI-ESWT for ED, demonstrated the significant improvements of penile hemodynamics after a 9 week trial of 12 sessions³. Thanks to all of this data, RegenerWave™ will soon become your first choice to treat Erectile Dysfunction.



1.  Cotran, R. Robbins Pathologic Basis of Disease. 6th edition. 1999.
2. Wang, C. Shock wave therapy induces neovascularization at the tendon-bone junction. A study in rabbits. Journal of Orthopaedic Research. 2003; 21:984-989.
3. Kalyvianakis D. Low-Intensity Shockwave Therapy Improved Hemodynamic Parameters in Patients With Vasculogenic Erectile Dysfunction: A Triplex Ultrasonography-Based Sham-Controlled Trial. The Journal of Sexual Medicine. 2017; 14: 891-897.